ISDIN stands for quality and trust. With over 40 years of experience and a commitment to research, the brand has become a leader in pharmaceutical skincare products. Under various names, ISDIN markets its products with a consistent philosophy: maximum efficacy and safety. From sun protection to treatments for atopic skin and anti-mosquito solutions, ISDIN offers a wide range of products to address your everyday needs.
This night facial cream is formulated with Melatonin to boost antioxidant defences, Carnosine to delay Advanced Glycation End-products (A.G.E.) formation, protecting collagen and elastin. Helichrysum Italicum stimulates calming molecules, enhancing well-being.
I was skeptical about retinal serums, but after a couple of weeks, my skin does seem brighter. Still early days, but I'm cautiously optimistic.
Alice Poppy | 19/04/2026
First time trying a retinal serum... I think it's working? My skin feels smoother. I'm using it now that it's getting colder, my face gets so dry in the winter. So far so good!
Mary Jane | 15/01/2026
Pues... la verdad es que lo estoy usando solo por la noche, después de limpiar bien la piel y antes de la crema hidratante. A ver si noto algo en unas semanas... De momento, bien.
Anna Grace | 19/12/2025
I have super sensitive skin, so I'm always wary of trying new retinols. This one didn't cause any redness or irritation for me, which is a win! Seems to be working well so far.
Wren | 29/08/2025
I switched to this from another brand because I wasn't seeing results. This one actually seems to be making a difference in my skin texture. It's smoother and looks brighter. I've been using it for about a month now.
Anna Grace | 23/08/2025
My derm told me to get a retinal serum so I grabbed this one fast delivery. Skin feels smoother already less textured. Noticed a slight difference in fine lines too. No irritation so far which is great. Good stuff.
Mary Jane | 17/08/2025
Was looking at other retinols but this one felt lighter on my skin. No strong smell.
Erin Brooke | 03/08/2025
I use this serum at night after cleansing and before my moisturizer. I've noticed a definite improvement in the texture of my skin. Fine lines are less visible, and my skin feels smoother. A great addition to my routine.
Tiernan | 17/07/2025
Absorbs quick no greasy residue feels good on skin.
Blaine | 12/05/2025
Product as expected. Well wrapped and quickly despatched. Price was competitive as well
Marlyn | 16/04/2026 09:21:40
5 stars supplier! Fast dispatch, well packed, fairly priced. It is the third time I am using this supplier. Before I used other suppliers, however, event including delivery to the Ireland, it is still the best offer in the market.
Julia | 21/03/2026 19:45:39
I had a great experience with customer service. The staff was friendly, patient, and very helpful in resolving my issue quickly. It’s refreshing to deal with a company that truly values its customers. Highly recommend!
Jessica | 10/02/2026 22:02:39
Didn't need customer service which is the best sort! The website was easy to use and everything went as predicted. This was my first order but I would use Pharmacy Club again.
John | 25/01/2026 17:06:39
Customer service kept me informed. Delivery obviously takes a little longer from EU but very pleased with service and outcome. Would use Pharmacy Club again
Peter | 19/12/2025 06:53:39
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| 18001 Granada | |
| Online orders : +34 858952394 |
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Description
ISDIN
REVIEWS
How to use
Ingredients
Revitalize your skin with Retinal Smooth, a biphase facial night serum formulated with retinaldehyde and matrikines that gently accelerates skin renewal, helping to prevent early signs of aging and promoting a more radiant complexion. Perfect for those starting to use retinal for anti-aging benefits.
Benefits:
Brightens: With retinaldehyde and matrikines, it boosts skin radiance by +40% in 4 weeks. Repairs: Melatonin provides antioxidant action, helping to repair damage caused by free radicals. Soothes: Niacinamide alleviates redness and softens the skin, providing a comforting sensation. Hydrates: Enhances hydration, keeping skin nourished. Directions for Use:
Apply Retinal Smooth during your nighttime routine. If you experience discomfort, follow a retinization period: in the first week, apply three nights per week with 2-night intervals; in the second week, use every other night; from the third week onwards, if no irritation occurs, increase usage frequency.
Key Ingredients:
Retinaldehyde: Known for its renewing effect, it reduces early fine lines. Matrikines: Peptides that promote microcirculation and skin renewal. Melatonin: Repairs oxidative damage overnight. Niacinamide: Soothes redness and improves hydration.
Shop Online Isdinceutics Retinal Smooth Serum 50 ml at best price.
Product features:
- Treatments: Anti-wrinkle and Anti-aging
- Cosmetic Type: High End
- Textures: Serum
- Best Sellers: Retinol
- Skin Type: All Skin Types
Product Reference: #371388
Directions for Use:1. Cleanse your face thoroughly in the evening before applying the serum. 2. Shake the bottle well to mix the two phases. 3. Dispense a small amount of serum onto your fingertips. 4. Gently apply the serum to your face and neck, avoiding the eye contour area. 5. Allow the serum to absorb fully before applying any other skincare products. 6. If you are new to retinoids or have sensitive skin, start with a retinization period: Week 1: Apply three nights a week with 2-night intervals. Week 2: Apply every other night. Week 3 onwards: If no irritation occurs, apply nightly.
Recommended Frequency: Apply Isdinceutics Retinal Smooth Serum every night after cleansing for optimal results. If irritation occurs, reduce the frequency as described in the retinization period above.
Additional Tips:1. Always perform a patch test before the first application, especially if you have sensitive skin. 2. Sun Sensitivity: Retinaldehyde can increase sun sensitivity. Always use a broad-spectrum sunscreen with an SPF of 30 or higher during the day while using this product and for a week after discontinuing use.
3. Avoid Eye Area: Do not apply the serum to the eye contour area.
4. Consult a Dermatologist: If you experience persistent irritation or have any concerns, consult a dermatologist.
5. Storage: Store the product in a cool, dry place away from direct sunlight.
6. Combination with other products: Avoid using other exfoliating products simultaneously with this serum to prevent irritation.
7. Introduce Gradually: If you are using other active ingredients in your skincare routine, introduce this serum gradually to avoid potential interactions.